منابع مشابه
RNA Polymerase Clamps Down
RPB1 (which is not present in bacterial RNAP) is not Gene expression in all cells requires synthesis of mRNAs resolved in the structures. by an evolutionarily conserved, multisubunit RNA polyAs RNAP transcribes (Figure 1B), DNA enters the enmerase (RNAP). A series of recent breakthroughs in zyme in the first chamber, termed the jaw-lobe module. X-ray crystallography of RNAP has begun to reveal ...
متن کاملSurge Suppressors and Clamps
A tutorial paper with a review of the technologies available in the mid-eighties for surge protection of lowvoltage end-user equipment. The principles of operation are described for “crowbar devices” (now generally described under the standardized name of “voltage switching devices”) and for “voltage clamping devices: (now generally described under the standardized name of “voltage limiting dev...
متن کاملClamp loaders and sliding clamps.
A coherent view of the structure and function of DNA polymerase processivity factors (sliding clamps and clamp loaders) is emerging from recent structural studies. Crystal structures of sliding clamps from the T4 and RB69 bacteriophages, and from an archaebacterium expand the gallery of ring-shaped processivity factors and clarify how the clamp interacts with the DNA polymerase. Crystallographi...
متن کاملProtein trafficking on sliding clamps.
The sliding clamps of chromosomal replicases are acted upon by both the clamp loader and DNA polymerase. Several other proteins and polymerases also interact with the clamp. These proteins bind the clamp at the same spot and use it in sequential fashion. First the clamp loader must bind the clamp in order to load it onto DNA, but directly thereafter the clamp loader must clear away from the cla...
متن کاملSliding Clamps: An Open and Shut Case?
Molecular events in the clamp-loading reaction pathway of DNA replication are revealed by new crystal structures of bacteriophage T4 clamp loader-clamp-DNA complexes that capture two distinct conformations with the clamp open and closed.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Canadian Medical Association Journal
سال: 2012
ISSN: 0820-3946,1488-2329
DOI: 10.1503/cmaj.111665